Schedule: Detroit Lions
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| Home Team | Away Team | Home Score | Away Score | Record | Game Date | Win |
|---|---|---|---|---|---|---|
| Green Bay Packers | Detroit Lions | 27 | 13 | 0-1 | 09-07-2025 | 0 |
| Detroit Lions | Chicago Bears | 52 | 21 | 1-1 | 09-14-2025 | 1 |
| Baltimore Ravens | Detroit Lions | 30 | 38 | 2-1 | 09-22-2025 | 1 |
| Detroit Lions | Cleveland Browns | 34 | 10 | 3-1 | 09-28-2025 | 1 |
| Cincinnati Bengals | Detroit Lions | 24 | 37 | 4-1 | 10-05-2025 | 1 |
| Kansas City Chiefs | Detroit Lions | 30 | 17 | 4-2 | 10-12-2025 | 0 |
| Detroit Lions | Tampa Bay Buccaneers | 24 | 9 | 5-2 | 10-20-2025 | 1 |
| Detroit Lions | Minnesota Vikings | 24 | 27 | 5-3 | 11-02-2025 | 0 |
| Washington Commanders | Detroit Lions | 22 | 44 | 6-3 | 11-09-2025 | 1 |
| Philadelphia Eagles | Detroit Lions | 16 | 9 | 6-4 | 11-16-2025 | 0 |
| Detroit Lions | New York Giants | 34 | 27 | 7-4 | 11-23-2025 | 1 |
| Detroit Lions | Green Bay Packers | 24 | 31 | 7-5 | 11-27-2025 | 0 |
| Detroit Lions | Dallas Cowboys | 44 | 30 | 8-5 | 12-04-2025 | 1 |
| Los Angeles Rams | Detroit Lions | 41 | 34 | 8-6 | 12-14-2025 | 0 |
| Detroit Lions | Pittsburgh Steelers | 24 | 29 | 8-7 | 12-21-2025 | 0 |
| Minnesota Vikings | Detroit Lions | 23 | 10 | 8-8 | 12-25-2025 | 0 |
| Chicago Bears | Detroit Lions | 16 | 19 | 9-8 | 01-04-2026 | 1 |